蛋白质/抗原/多肽 >> 重组蛋白
重组软骨中间层蛋白2(CILP2)
半岛bd体育手机客户端 介绍
基因名:
Cilp2 半岛bd体育手机客户端 别名: 1110031K21Rik; AA407300; CLIP-2; Cilp2; cartilage intermediate layer protein 2; cartilage intermediate layer protein 2; 软骨中间层蛋白2(CILP2); 软骨中间层蛋白CILP2; 背景信息:
Cartilage intermediate layer protein (CILP), an extracellular matrix protein, shows abundant expression in cartilagenous tissues. CILP is expressed as two isoforms, CILP and CILP-2, which are differentially expressed by chondrocytes and induced by TGF∫1. This induction is mediated by Smad3 through direct interactions with cis-elements in the CILP promoter region. TGF∫ also induces elevated chondrocyte extracellular inorganic pyrophosphate (PPi), which promotes the deposition of calcium pyrophosphate dihydrate crystals. The CILP isoforms have been implicated in common musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis and lumbar disc disease.
标签:His-tag |
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