蛋白质/抗原/多肽 >> 重组蛋白
重组细胞膜蛋白Derlin
半岛bd体育手机客户端 介绍
基因名:
Derl1 半岛bd体育手机客户端 别名: 1110021N07Rik; AI195141; AW551338; Derlin-1; Derl1; Der1-like domain family, member 1; Der1-like domain family, member 1; derlin-1; degradation in endoplasmic reticulum protein 1; der1-like protein 1; 细胞膜蛋白Derlin; 背景信息:
Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.
标签:His-tag |
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