蛋白质/抗原/多肽 >> 重组蛋白
重组肿瘤抗原CML66蛋白
半岛bd体育手机客户端 介绍
基因名:
Nudcd1 半岛bd体育手机客户端 别名: 4921532K09Rik; AA407246; AW260430; AW556235; CML66-L; Cml66; Nudcd1; NudC domain containing 1; NudC domain containing 1; nudC domain-containing protein 1; chronic myelogenous leukemia tumor antigen 66; 肿瘤抗原CML66; 背景信息:
The NUDCD1 gene encodes the 583 amino acid CML66 protein which demonstrates expression in a variety of solid tumor cell lines and leukemias. Expression of CML66 in normal tissues is restricted to testis and heart. The CML66 antibody is found in sera of 18-38% of patients with lung cancer, melanoma or prostate cancer. These findings indicate that CML66 may be immunogenic in a wide variety of malignancies and may be a target for antigen-specific immunotherapy. A short isoform of CML66, designated CML66-S, is a product of alternative splicing. CML66-S has the same C-terminus as full-lenghth CML66 (also designated CML66-L), but has a unique N-terminus. CML66-S shows predominant expression in testis, and is also expressed in very low levels in tumor cells, while CML66 is expressed in tumor cells and testis.
标签:His-tag |
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