蛋白质/抗原/多肽 >> 重组蛋白
重组中心体肌动蛋白γ1/增强型PI3K蛋白
半岛bd体育手机客户端 介绍
基因名：
Agap2 半岛bd体育手机客户端 别名： Centg1； Pike； Agap2； ArfGAP with GTPase domain, ankyrin repeat and PH domain 2； ArfGAP with GTPase domain, ankyrin repeat and PH domain 2； arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2； AGAP-2； centaurin, gamma 1； cnt-g1； nuclear GTPase PIKE； phosphatidylinositol 3-kinase enhancer； 中心体肌动蛋白γ1/增强型PI3K蛋白； 背景信息：
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
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