蛋白质/抗原/多肽 >> 重组蛋白
重组GALNT11蛋白
半岛bd体育手机客户端 介绍
基因名:
GALNT11 半岛bd体育手机客户端 别名: GALNAC-T11; GALNACT11; GALNT11; polypeptide N-acetylgalactosaminyltransferase 11; polypeptide N-acetylgalactosaminyltransferase 11; polypeptide N-acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11); polypeptide GalNAc transferase 11; pp-GaNTase 11; protein-UDP acetylgalactosaminyltransferase 11; 背景信息:
The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T11 (Polypeptide N-acetylgalactosaminyltransferase 11), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11, is a 608 amino acid protein that catalyzes glycosylation of Muc1, Muc4.1 and EA2, though it does not display enzymatic preference for erythropoitein. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. GalNAc-T11 is highly expressed in kidney tubules, though it is not expressed in glomeruli. There are two isoforms of GalNAc-T11 that are produced as a result of alternative splicing events.
标签:His-tag |
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