蛋白质/抗原/多肽 >> 重组蛋白
重组扣带蛋白
半岛bd体育手机客户端 介绍
基因名:
CGN 半岛bd体育手机客户端 别名: CGN; cingulin; cingulin; 扣带蛋白; 背景信息:
Diffusion of solutes is prevented across certain barriers by the formation of tight junction seals. Occludin and Cingulin interact with other proteins to direct the formation and regulation of tight junctions. Cingulin, a protein component of the submembrane plaque of tight junctions (TJ), contains globular and coiled-coil domains and interacts in vitro with several TJ and cytoskeletal proteins, including the PDZ protein ZO-1. Cingulin binding has also been shown to inhibit RhoA activation and signaling with increased Cingulin expression in confluent cells, causing downregulation of RhoA by inhibiting GEF-H1/Lfc.
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