蛋白质/抗原/多肽 >> 重组蛋白
重组T细胞2识别黑色素瘤抗原蛋白
半岛bd体育手机客户端 介绍
基因名：
HHATL 半岛bd体育手机客户端 别名： C3orf3； GUP1； MBOAT3； MSTP002； OACT3； HHATL； hedgehog acyltransferase like； hedgehog acyltransferase like； protein-cysteine N-palmitoyltransferase HHAT-like protein； GUP1 glycerol uptake/transporter homolog； glycerol uptake/transporter homolog； hedgehog acyltransferase-like protein； membrane bound O-acyltransferase domain containing 3； T细胞2识别黑色素瘤抗原； 甘油吸收/转运蛋白GUP1； 背景信息：
GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.
标签：His-tag |
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