蛋白质/抗原/多肽 >> 重组蛋白
重组连接蛋白3(JPH3)
半岛bd体育手机客户端 介绍
基因名:
JPH3 半岛bd体育手机客户端 别名: CAGL237; HDL2; JP-3; JP3; TNRC22; JPH3; junctophilin 3; junctophilin 3; junctophilin-3; junctophilin type 3; trinucleotide repeat containing 22; 连接蛋白3(JPH3); 连接蛋白JPH3; 背景信息:
Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells. Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, as well as an ER/SR membrane spanning hydrophobic C-terminal segment. The three subtypes in this family are Junctophilin-1, -2 and -3. Junctophilin-1 is predominantly expressed in skeletal muscle, but is also expressed at low levels in heart. Junctophilin-2 is expressed in heart and skeletal muscle. Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients. Junctophilin-3 is expressed in brain. The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder.
标签:His-tag |
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