蛋白质/抗原/多肽 >> 重组蛋白
重组14号染色体开放阅读框106蛋白
半岛bd体育手机客户端 介绍
基因名:
MIS18BP1 半岛bd体育手机客户端 别名: C14orf106; HSA242977; KNL2; M18BP1; MIS18BP1; MIS18 binding protein 1; MIS18 binding protein 1; mis18-binding protein 1; P243; hsKNL-2; kinetochore null 2 homolog; kinetochore-associated protein KNL-2 homolog; putative protein p243 which interacts with transcription factor Sp1; 14号染色体开放阅读框106; 背景信息:
C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.
标签:His-tag |
相关半岛bd体育手机客户端
|