半岛bd体育手机客户端 介绍
基因名：
MARCHF1 半岛bd体育手机客户端 别名： MARCH-I； MARCH1； RNF171； MARCHF1； membrane associated ring-CH-type finger 1； membrane associated ring-CH-type finger 1； E3 ubiquitin-protein ligase MARCHF1； E3 ubiquitin-protein ligase MARCH1； RING finger protein 171； RING-type E3 ubiquitin transferase MARCH1； RING-type E3 ubiquitin transferase MARCHF1； membrane associated ring finger 1； membrane-associated RING finger protein 1； membrane-associated RING-CH protein I； membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase； 膜相关环指蛋白1； 背景信息：
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, downregulates their cell surface localization thus sequestering them in the intracellular endosomal system.
标签：His-tag |
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