半岛bd体育手机客户端 介绍
基因名：
ZDHHC3 半岛bd体育手机客户端 别名： DHHC-3； DHHC3； GODZ； ZNF373； ZDHHC3； zinc finger DHHC-type palmitoyltransferase 3； zinc finger DHHC-type palmitoyltransferase 3； palmitoyltransferase ZDHHC3； DHHC1 protein； Golgi apparatus-specific protein with DHHC zinc finger domain； acyltransferase ZDHHC3； golgi-specific DHHC Zinc Finger Protein； zinc finger DHHC domain-containing protein 3； zinc finger DHHC-type containing 3； zinc finger protein 373； zinc finger, DHHC domain containing 3； 棕榈酰转移酶GODZ； 背景信息：
Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ), also known as, Palmitoyltransferase ZDHHC3 or Zinc finger protein 373, is a 327 amino acid protein member of the DHHC palmitoyltransferase family. Localized to the Golgi apparatus membrane, GODZ contains one DHHC-type zinc finger, which is necessary for its palmitoyltransferase activity. GODZ has been implicated in the palmitoylation and regulated trafficking of diverse substrates that function various inhibitory and excitatory synapses. Specifically, it palmitoylates the gamma subunit 2 of GABA(A) receptors, which leads to normal synaptic GABAergic inhibitory function. GODZ also palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. Two isoforms of GODZ exist as a result of alternative splicing events.
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