蛋白质/抗原/多肽 >> 重组蛋白
重组鞘磷脂沉积病C1样蛋白1
半岛bd体育手机客户端 介绍
基因名:
NPC1L1 半岛bd体育手机客户端 别名: LDLCQ7; NPC11L1; SLC65A2; NPC1L1; NPC1 like intracellular cholesterol transporter 1; NPC1 like intracellular cholesterol transporter 1; NPC1-like intracellular cholesterol transporter 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; niemann-Pick C1-like protein 1; 鞘磷脂沉积病C1样蛋白1; 背景信息:
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
标签:His-tag |
相关半岛bd体育手机客户端
|