蛋白质/抗原/多肽 >> 重组蛋白
重组锚蛋白重复结构域蛋白11
半岛bd体育手机客户端 介绍
基因名:
ANKRD11 半岛bd体育手机客户端 别名: ANCO-1; ANCO1; LZ16; T13; ANKRD11; ankyrin repeat domain containing 11; ankyrin repeat domain containing 11; ankyrin repeat domain-containing protein 11; ankyrin repeat domain 11; ankyrin repeat-containing cofactor 1; ankyrin repeats containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; 锚蛋白重复结构域蛋白11; 背景信息:
Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22–24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.
标签:His-tag |
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