鍩哄洜鍚嶏細

CSDC2

浜у搧鍒悕锛欬p style="text-indent: 2em;">PIPPIN锛 dJ347H13.2锛 CSDC2锛 cold shock domain containing C2锛 cold shock domain containing C2锛 cold shock domain-containing protein C2锛 RNA-binding protein pippin锛 cold shock domain containing C2, RNA binding锛 鍐蜂紤鍏嬬粨鏋勫煙铔嬬櫧C2锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3鈥?UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis.