鍩哄洜鍚嶏細

GMEB2

浜у搧鍒悕锛欬p style="text-indent: 2em;">GMEB-2锛 P79PIF锛 PIF79锛 GMEB2锛 glucocorticoid modulatory element binding protein 2锛 glucocorticoid modulatory element binding protein 2锛 glucocorticoid modulatory element-binding protein 2锛 DNA-binding protein p79PIF锛 PIF p79锛 parvovirus initiation factor, p79锛 绯栫毊璐ㄦ縺绱犺皟鑺傚厓浠剁粨鍚堣泲鐧?锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.