蛋白质/抗原/多肽 >> 重组蛋白
重组葡萄糖醛酸差向异构酶蛋白
半岛bd体育手机客户端 介绍
基因名:
GLCE 半岛bd体育手机客户端 别名: HSEPI; GLCE; glucuronic acid epimerase; glucuronic acid epimerase; D-glucuronyl C5-epimerase; UDP-glucuronic acid epimerase; glucuronyl C5-epimerase; heparan sulfate C5-epimerase; heparan sulfate epimerase; heparin/heparan sulfate-glucuronic acid C5-epimerase; heparosan-N-sulfate-glucuronate 5-epimerase; 葡萄糖醛酸差向异构酶; 葡萄糖醛酸差向异构酶(GLCE); 背景信息:
GLCE (glucuronic acid epimerase), also known as HSEPI (heparin/heparan sulfate:glucuronic acid C5-epimerase) or D-glucuronyl C5-epimerase, is a single-pass type II membrane protein that is part of the golgi apparatus and, through its enzymatic activity, is essential for proper biological function of heparan sulphate (HS). GLCE epimerizes D-glucuronic acid into L-iduronic acid of HS, thus changing the specificity of HS and allowing it to bind to cytokines and growth factors. GLCE is a target of the beta-catenin–TCF4 transactivation complex; an essential component in the Wnt/APC/beta-catenin signaling pathway that is upregulated in colon carcinoma cells. The enzymatic activity of GLCE is enhanced by overexpression of beta-catenin–TCF4, suggesting a possible role for GLCE in the dysregulation of proper signaling pathways; a dysregulation that leads to the development of human epithelial tumors.
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