蛋白质/抗原/多肽 >> 重组蛋白
重组His结构域内含酪氨酸磷酸酶蛋白
半岛bd体育手机客户端 介绍
基因名:
PTPN23 半岛bd体育手机客户端 别名: HD-PTP; HDPTP; NEDBASS; PTP-TD14; PTPN23; protein tyrosine phosphatase non-receptor type 23; protein tyrosine phosphatase non-receptor type 23; tyrosine-protein phosphatase non-receptor type 23; his domain-containing protein tyrosine phosphatase; protein tyrosine phosphatase TD14; His结构域内含酪氨酸磷酸酶蛋白; 背景信息:
HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.
标签:His-tag |
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