鍩哄洜鍚嶏細

SHC2

浜у搧鍒悕锛欬p style="text-indent: 2em;">SCK锛 SHCB锛 SLI锛 SHC2锛 SHC adaptor protein 2锛 SHC adaptor protein 2锛 SHC-transforming protein 2锛 SH2 domain protein C2锛 SHC (Src homology 2 domain containing) transforming protein 2锛 SHC-transforming protein B锛 neuronal Shc adaptor homolog锛 protein Sck锛 src homology 2 domain-containing-transforming protein C2锛 SCK铔嬬櫧锛 SHC-杞寲铔嬬櫧2(SHC2)锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).