蛋白质/抗原/多肽 >> 重组蛋白
重组三核苷酸重复蛋白6B
半岛bd体育手机客户端 介绍
基因名:
TNRC6B 半岛bd体育手机客户端 别名: GDSBA; TNRC6B; trinucleotide repeat containing adaptor 6B; trinucleotide repeat containing adaptor 6B; trinucleotide repeat-containing gene 6B protein; trinucleotide repeat containing 6B; 三核苷酸重复蛋白6B; 背景信息:
TNRC6B is a 1,723 amino acid protein that exists as two alternatively spliced isoforms and is thought to be involved in mRNA cleavage events. Expressed ubiquitously, TNRC6B contains one glycine/tryptophan (GW)-rich N-terminal domain, one central glutamine-rich region and one C-terminal RNA recognition motif and is encoded by a gene that maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
标签:His-tag |
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