蛋白质/抗原/多肽 >> 重组蛋白
重组SH2B蛋白
半岛bd体育手机客户端 介绍
基因名:
Sh2b1 半岛bd体育手机客户端 别名: AI425885; C530001K22Rik; Irip; Psm; SH2-B; SH2-Bb; Sh2bpsm1; mKIAA1299; Sh2b1; SH2B adaptor protein 1; SH2B adaptor protein 1; SH2B adapter protein 1; SH2 domain-containing protein 1B; SH2-B PH domain containing signaling mediator 1; pro-rich, PH and SH2 domain-containing signaling mediator; SH2B蛋白; 背景信息:
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1.
标签:His-tag |
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