鍩哄洜鍚嶏細

Ptpn18

浜у搧鍒悕锛欬p style="text-indent: 2em;">FLP1锛 HSCF锛 PTP-HSCF锛 PTP-K1锛 Ptpk1锛 Ptpn18锛 protein tyrosine phosphatase, non-receptor type 18锛 protein tyrosine phosphatase, non-receptor type 18锛 tyrosine-protein phosphatase non-receptor type 18锛 FLP-1锛 fetal liver phosphatase 1锛 鑴戞簮鎬х７閰搁叾PTPN18锛 闈炲彈浣撳瀷铔嬬櫧閰皑閰哥７閰搁叾18(PTPN18)锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]