鍩哄洜鍚嶏細

Ccl21a

浜у搧鍒悕锛欬p style="text-indent: 2em;">6CKBAC2锛 6Ckine锛 ALP锛 AW987545锛 CKb9锛 Gm1987锛 SCYA21a锛 SLC锛 Scya21锛 Scya21b锛 Tca4锛 plt锛 Ccl21a锛 chemokine (C-C motif) ligand 21A (serine)锛 chemokine (C-C motif) ligand 21A (serine)锛 C-C motif chemokine 21a锛 CC chemokine 6Ckine-ser锛 CCL21-Ser锛 beta-chemokine exodus-2锛 exodus-2锛 small inducible cytokine A21a锛 thymus-derived chemotactic agent 4锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">C-C Motif Chemokine 21a (CCL21a) is a small secreted cytokine that belongs to the intercrine beta (CC chemokine) family. Mouse CCL21 cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Mouse CCL21 has three forms while CCL21a has Ser-65. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7 and CXCR3. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Mouse CCL21 shows preferential activity towards naive T-cells and may play a role in mediating homing of lymphocytes to secondary lymphoid organs.