鍩哄洜鍚嶏細

RASA4

浜у搧鍒悕锛欬p style="text-indent: 2em;">CAPRI锛 GAPL锛 RASA4锛 RAS p21 protein activator 4锛 RAS p21 protein activator 4锛 ras GTPase-activating protein 4锛 Ca2+-promoted Ras inactivator锛 calcium-promoted Ras inactivator锛 rasGAP-activating-like protein 2锛 GTP閰舵縺娲昏泲鐧芥牱RASA4锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]