半岛bd体育手机客户端 介绍
基因名：
PLPPR4 半岛bd体育手机客户端 别名： LPPR4； LPR4； PHP1； PRG-1； PRG1； PLPPR4； phospholipid phosphatase related 4； phospholipid phosphatase related 4； phospholipid phosphatase-related protein type 4； 2-lysophosphatidate phosphatase PLPPR4； brain-specific phosphatidic acid phosphatase-like protein 1； inactive 2-lysophosphatidate phosphatase PLPPR4； lipid phosphate phosphatase-related protein type 4； plasticity related gene 1； plasticity-related gene 1 protein； 脑特异性磷脂酸磷酸酶样蛋白1； 背景信息：
Phosphatidate phosphatases are a family of integral membrane glycoproteins that dephosphorylate a variety of lipid phosphates and play a role in signal transduction via the phospholipase D pathway. PAP-2 proteins function independently of Mg2+ and are insensitive to NEM (N-ethylmaleimide) inhibition. The lipid phosphates degraded by this family include ceramide 1-phosphate (C1P), sphingosine 1-phosphate (S1P), phosphatidic acid (PA) and lysophosphatidic acid (LPA). LPPR4 (lipid phosphate phosphatase-related protein type 4), also known as LPR4, PHP1, PRG1 or PRG-1, is a 763 amino acid multi-pass membrane protein that belongs to the PA-phosphatase related phosphoesterase family. Exclusively expressed in neurons, LPPR4 hydrolyzes lysophosphatidic acid (LPA) and facilitates axonal outgrowth during development and regenerative sprouting. LPPR4 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 1p21.2.
标签：His-tag |
相关半岛bd体育手机客户端
|
