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重组LRIG2蛋白
半岛bd体育手机客户端 介绍
基因名:
LRIG2 半岛bd体育手机客户端 别名: LIG-2; LIG2; UFS2; LRIG2; leucine rich repeats and immunoglobulin like domains 2; leucine rich repeats and immunoglobulin like domains 2; leucine-rich repeats and immunoglobulin-like domains protein 2; 背景信息:
LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion.
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