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重组EDEM1蛋白
半岛bd体育手机客户端
介绍 基因名: EDEM1 半岛bd体育手机客户端 别名: EDEM; EDEM1; ER degradation enhancing alpha-mannosidase like protein 1; ER degradation enhancing alpha-mannosidase like protein 1; ER degradation-enhancing alpha-mannosidase-like protein 1; ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; EDEM1蛋白; 背景信息: Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p. 标签:His-tag |
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