鍩哄洜鍚嶏細

RNMT

浜у搧鍒悕锛欬p style="text-indent: 2em;">CMT1锛 CMT1c锛 MET锛 Met锛 N7-MTase锛 RG7MT1锛 cm1p锛 hCMT1锛 hMet锛 RNMT锛 RNA guanine-7 methyltransferase锛 RNA guanine-7 methyltransferase锛 mRNA cap guanine-N7 methyltransferase锛 RNA (guanine-7-) methyltransferase锛 hcm1p锛 mRNA (guanine-7-)methyltransferase锛 mRNA (guanine-N(7)-)-methyltransferase锛 mRNA cap methyltransferase锛 mRNA cap鐢插熀杞Щ閰讹紱

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">RNMT (RNA (guanine-7-) methyltransferase) is a widely expressed nuclear protein that belongs to the mRNA cap methyltransferase family. It is responsible for catalyzing the final step in the attachment of the m7GpppN cap to the 5' end of mRNA. Capping of mRNA plays an important role in mRNA processing, stability and translation and is therefore important for efficient gene expression. There are three enzymatic steps in the generation of the mRNA cap. The first two steps are catalyzed by RNGTT (RNA guanylyltransferase and 5' phosphatase), and the third step is catalyzed by RNMT. More specifically, RNMT catalyzes the transfer of a methyl group from AdoMet (S-adenosylmethionine) to the GpppN end of the growing mRNA at the N-7 position, thereby producing AdoHyc (S-adenosylhomocysteine) and m7GpppN terminated RNA. Two additional isoforms of RNMT exist due to alternative splicing events, namely hCMT1a and hCMT1b.