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蛋白质/抗原/多肽 >> 重组蛋白
重组转化/转录域关联蛋白(TRRAP)
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介绍 基因名: TRRAP 半岛bd体育手机客户端 别名: DEDDFA; DFNA75; PAF350/400; PAF400; STAF40; TR-AP; Tra1; TRRAP; transformation/transcription domain associated protein; transformation/transcription domain associated protein; transformation/transcription domain-associated protein; 350/400 kDa PCAF-associated factor; tra1 homolog; 转化/转录域关联蛋白(TRRAP); 转录因子相关蛋白TRRAP; 背景信息: The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5). 标签:His-tag |
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