蛋白质/抗原/多肽 >> 重组蛋白
重组环指蛋白105
半岛bd体育手机客户端 介绍
基因名:
TTC3 半岛bd体育手机客户端 别名: DCRR1; RNF105; TPRDIII; TTC3; tetratricopeptide repeat domain 3; tetratricopeptide repeat domain 3; E3 ubiquitin-protein ligase TTC3; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; TPR repeat protein 3; TPR repeat protein D; tetratricopeptide repeat protein 3; 环指蛋白105; 背景信息:
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
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