鍩哄洜鍚嶏細

RAP2A

浜у搧鍒悕锛欬p style="text-indent: 2em;">K-REV锛 KREV锛 RAP2锛 RbBP-30锛 RAP2A锛 RAP2A, member of RAS oncogene family锛 RAP2A, member of RAS oncogene family锛 ras-related protein Rap-2a锛 RAP2, member of RAS oncogene family (K-rev)锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Ras oncogenes encode GTP-binding proteins that are capable of transforming immortalized cells in culture. Two Ras-related human genes, designated RAP1A and RAP1B, encode 95% homologous proteins (namely Rap 1A and Rap 1B) that share a similar C-terminal Cys-Ali-Ali-Xaa sequence with Ras proteins and are ubiquitously expressed in mammalian tissues. The putative 鈥渆ffector鈥 domain of Ras proteins, whose integrity is required for cell transformation as well as interaction with the putative effector protein GAP, is conserved in both Rap 1 proteins. Rap 1A is thought to interfere with Ras effector function by binding to Ras GAP in a GTP-dependent manner without affecting Rap 1A GTPase activity. Rap 2, another Ras-related protein, shares 60% identity with Rap 1A and exhibits a carboxy terminal CAAX motif and two upstream cysteines similar to those of the H-Ras, K-Ras and N-Ras proteins. In contrast with Rap 1A and Rap 1B, overexpression of Rap 2 does not interfere with the Ras signaling pathway.