蛋白质/抗原/多肽 >> 重组蛋白
重组大脑蛋白1
半岛bd体育手机客户端 介绍
基因名:
POU3F3 半岛bd体育手机客户端 别名: BRN1; OTF8; SNIBFIS; brain-1; oct-8; POU3F3; POU class 3 homeobox 3; POU class 3 homeobox 3; POU domain, class 3, transcription factor 3; brain-specific homeobox/POU domain protein 1; octamer-binding protein 8; octamer-binding transcription factor 8; 大脑蛋白1; 背景信息:
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.
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