蛋白质/抗原/多肽 >> 重组蛋白
重组T细胞白血病淋巴瘤蛋白3
半岛bd体育手机客户端 介绍
基因名:
TLX1 半岛bd体育手机客户端 别名: HOX11; TCL3; TLX1; T cell leukemia homeobox 1; T cell leukemia homeobox 1; T-cell leukemia homeobox protein 1; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); homeobox protein Hox-11; proto-oncogene TCL-3; T细胞白血病淋巴瘤蛋白3; 背景信息:
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed.
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