蛋白质/抗原/多肽 >> 重组蛋白
重组α增强子结合蛋白1
半岛bd体育手机客户端 介绍
基因名：
ZFHX3 半岛bd体育手机客户端 别名： ATBF1； ATBT； C16orf47； ZFH-3； ZNF927； ZFHX3； zinc finger homeobox 3； zinc finger homeobox 3； zinc finger homeobox protein 3； AT motif-binding factor 1； AT-binding transcription factor 1； alpha-fetoprotein enhancer binding protein； zinc finger homeodomain protein 3； α增强子结合蛋白1； 背景信息：
AT-motif binding factor 1 (ATBF1) binds to the AT-rich core sequence element in the human a-fetoprotein enhancer (1). Alternative splicing generates the ATBF1-A and ATBF1-B (2,3). While ATBF1-A contains a 920-amino acid extension at the N-terminus, both ATBF1-A and ATBF1-B contain 4 DNA-binding homeobox domains (2,3). Additionally, ATBF1-A contains 23 zinc finger motifs while ATBF1-B contains 18 zinc finger motifs (1–3). The N-terminal extension unique to ATBF1-A has transcriptional repressor activity (4). In the small intestine, ATBF1-A inhibits expression of the brushborder enzyme aminopeptidase-N through direct binding to the AT motif element (5). Besides functioning in transcription regulation, ATBF1 also functions in ATPase activity (6). ATPase activity associated with ATBF1-A is DNA/RNA-dependent and requires both homeobox domains and zinc finger motifs (6). ATBF1 is highly expressed in spleen and brain tissues (7). The gene encoding human ATBF1 maps to chromosome 16q22.3-q23.1 (8).
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