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8号染色体开放阅读框77抗体
半岛bd体育手机客户端 介绍
靶标:
ZNF252P-AS1 半岛bd体育手机客户端 别名: C8orf77; ZNF252P-AS1; ZNF252P antisense RNA 1; ZNF252P antisense RNA 1; ZNF252P antisense RNA 1 (non-protein coding); 8号染色体开放阅读框77; 背景信息:
C8orf77 (chromosome 8 open reading frame 77) is a 211 amino acid protein encoded by a gene that maps to human chromosome 8q24.3. Consisting of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
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