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Als2cl抗体
半岛bd体育手机客户端 介绍
靶标:
Als2cl 半岛bd体育手机客户端 别名: 79H19D; 79H19E; BC022645; D930044G19Rik; mRn.49018; Als2cl; ALS2 C-terminal like; ALS2 C-terminal like; ALS2 C-terminal-like protein; mFLJ00189 protein; 背景信息:
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity.
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