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锌指/环指蛋白2抗体
半岛bd体育手机客户端 介绍
靶标：
ZNRF2 半岛bd体育手机客户端 别名： RNF202； ZNRF2； zinc and ring finger 2； zinc and ring finger 2； E3 ubiquitin-protein ligase ZNRF2； RING finger protein 202； RING-type E3 ubiquitin transferase ZNRF2； protein Ells2； zinc and ring finger 2, E3 ubiquitin protein ligase； zinc finger/RING finger 2； zinc/RING finger protein 2； 锌指/环指蛋白2； 背景信息：
domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,
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