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GEN1蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
Gen1 半岛bd体育手机客户端 别名: 5830483C08Rik; Gen1; GEN1, Holliday junction 5' flap endonuclease; GEN1, Holliday junction 5' flap endonuclease; flap endonuclease GEN homolog 1; Gen homolog 1, endonuclease; GEN1蛋白; 背景信息:
This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],
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