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磷酸二酯酶12(PDE12)抗体
半岛bd体育手机客户端 介绍
靶标:
PDE12 半岛bd体育手机客户端 别名: 2'-PDE; 2-PDE; PDE12; phosphodiesterase 12; phosphodiesterase 12; 2',5'-phosphodiesterase 12; 2'-phosphodiesterase; mitochondrial deadenylase; 磷酸二酯酶12(PDE12); 背景信息:
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs. Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.
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