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14号染色体开放阅读框146抗体
半岛bd体育手机客户端 介绍
靶标:
LRFN5 半岛bd体育手机客户端 别名: C14orf146; FIGLER8; SALM5; LRFN5; leucine rich repeat and fibronectin type III domain containing 5; leucine rich repeat and fibronectin type III domain containing 5; leucine-rich repeat and fibronectin type-III domain-containing protein 5; fibronectin type III, immunoglobulin and leucine rich repeat domains 8; 14号染色体开放阅读框146; 背景信息:
LRFN5 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
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