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DCN1样蛋白3抗体
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DCUN1D3 半岛bd体育手机客户端 别名： 44M2.4； DCNL3； SCCRO3； DCUN1D3； defective in cullin neddylation 1 domain containing 3； defective in cullin neddylation 1 domain containing 3； DCN1-like protein 3； DCN1, defective in cullin neddylation 1, domain containing 3； DCUN1 domain-containing protein 3； defective in cullin neddylation protein 1-like protein 3； squamous cell carcinoma-related oncogene 3； DCN1样蛋白3； 背景信息：
Covalent attachment of NEDD8 to cullins, a process called neddylation, results in nuclear cullin accumulation, which promotes cell growth, migration, and transformation. DCUN1D3 inhibits neddylation of cullins by sequestering them to the plasma membrane, thereby promoting cell differentiation. Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).
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