闈舵爣锛欬p style="text-indent: 2em;">Rnf169

浜у搧鍒悕锛欬p style="text-indent: 2em;">2900057K09Rik锛 Rnf169锛 ring finger protein 169锛 ring finger protein 169锛 E3 ubiquitin-protein ligase RNF169锛 RING-type E3 ubiquitin transferase RNF169锛 鐜寚铔嬬櫧169锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">RING finger protein 169 (RNF169) is a probable E3 ubiquitin-protein ligase that acts as a negative regulator of the repair of double-strand breaks (DSBs) following DNA damage. RNF169 is recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSB repair. This gene is mapped to 11q13.4.