闈舵爣锛欬p style="text-indent: 2em;">Champ1

浜у搧鍒悕锛欬p style="text-indent: 2em;">AA675043锛 AI116001锛 D8Ertd457e锛 D8Ertd569e锛 Zfp828锛 Znf828锛 mKIAA1802锛 Champ1锛 chromosome alignment maintaining phosphoprotein 1锛 chromosome alignment maintaining phosphoprotein 1锛 chromosome alignment-maintaining phosphoprotein 1锛 zinc finger protein 828锛 閿屾寚铔嬬櫧828锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">CHAMP1 (chromosome alignment maintaining phosphoprotein 1), also known as ZNF828 or C13orf8, is a 812 amino acid protein containing one C2H2-type zinc finger. CHAMP1 is required for the proper alignment of chromosomes during metaphase, undergoing CDK1-dependent phosphorylation at multiple sites during mitosis. The phosphorylation counteracts the negative chromosomal alignment regulation of the zinc-finger domain of CHAMP1. One region of CHAMP1, the FPE region, is responsible for spindle and kinetochore localization, which is essential for proper chromosome alignment. CHAMP1 interacts with MAD2L2, PGOZ, CBX1, CBX3 and CBX5, and may recruit CENPE and CENPF to the kinetochore. The CHAMP1 gene is located on chromosome 13 and is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat and chicken.