半岛bd体育手机客户端 介绍
靶标:
Dnajc24 半岛bd体育手机客户端 别名: 1700030A21Rik; 2610027M02Rik; AV066965; AW240712; Dph4; MmDjC7; Zcsl3; Dnajc24; DnaJ heat shock protein family (Hsp40) member C24; DnaJ heat shock protein family (Hsp40) member C24; dnaJ homolog subfamily C member 24; CSL-type zinc finger-containing protein 3; DPH4 homolog (JJJ3, S. cerevisiae); DnaJ (Hsp40) homolog, subfamily C, member 24; diphthamide biosynthesis protein 4; j domain protein DjC7; zinc finger, CSL-type containing 3; DPH4蛋白; 背景信息:
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).
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