闈舵爣锛欬p style="text-indent: 2em;">PIGY

浜у搧鍒悕锛欬p style="text-indent: 2em;">HPMRS6锛 PIG-Y锛 PIGY锛 phosphatidylinositol glycan anchor biosynthesis class Y锛 phosphatidylinositol glycan anchor biosynthesis class Y锛 phosphatidylinositol N-acetylglucosaminyltransferase subunit Y锛 phosphatidylinositol-glycan biosynthesis class Y protein锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Glycosylphosphatidylinositol (GPI) lipid anchoring is an important post-translational modification of proteins that takes place in the endoplasmic reticulum. The synthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), a complex of proteins including PIG-A, PIG-H, PIG-C, GPI1, and DPM2. PIG-Y, the mammalian homolog to yeast Eri1p, is also thought to be involved in the biosynthesis of GPI. The PIG-Y gene encodes two proteins, one of which arises from leaky scanning of the mRNA. This antibody only detects isoform 1 of PIG-Y. Despite its predicted molecular weight, PIG-Y often migrates at 28-30 kDa in SDS-PAGE.