半岛bd体育手机客户端 介绍
靶标：
PLEKHA8 半岛bd体育手机客户端 别名： FAPP2； PLEKHA8； pleckstrin homology domain containing A8； pleckstrin homology domain containing A8； pleckstrin homology domain-containing family A member 8； PH domain-containing family A member 8； phosphatidylinositol 4-phosphate adaptor protein-2； phosphatidylinositol-four-phosphate adapter protein 2； phosphoinositol 4-phosphate adapter protein 2； pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8； serologically defined breast cancer antigen NY-BR-86； FAPP2蛋白； 背景信息：
The phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2, also known as PLEKHA8) gene encodes a cytoplasmic lipid transferase with a plekstrin homology domain that has been implicated in vesicle maturation and transport from trans-Golgi to the plasma membrane. FAPP2 plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing. FAPP2, a PI4P effector and glycosphingolipid-binding protein, is recruited to the hepatitis C virus (HCV) replication complex and is required for HCV genome replication and replication complex formation.
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