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PRAM1蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
PRAM1 半岛bd体育手机客户端 别名: PML-RAR; PRAM-1; PRAM1; PML-RARA regulated adaptor molecule 1; PML-RARA regulated adaptor molecule 1; PML-RARA-regulated adapter molecule 1; PML-RARA target gene encoding an Adaptor Molecule-1; PRAM; PRAM1蛋白; 背景信息:
Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.
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