闈舵爣锛欬p style="text-indent: 2em;">KDM7A

浜у搧鍒悕锛欬p style="text-indent: 2em;">JHDM1D锛 KDM7A锛 lysine demethylase 7A锛 lysine demethylase 7A锛 lysine-specific demethylase 7A锛 [histone H3]-dimethyl-L-lysine9 demethylase 7A锛 histone lysine demethylase JHDM1D锛 jmjC domain-containing histone demethylation protein 1D锛 jumonji C domain containing histone demethylase 1 homolog D锛 lysine (K)-specific demethylase 7A锛 lysine-specific demethylase 7锛 JHDM1D铔嬬櫧锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.