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JHDM1D蛋白抗体
半岛bd体育手机客户端 介绍
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KDM7A 半岛bd体育手机客户端 别名： JHDM1D； KDM7A； lysine demethylase 7A； lysine demethylase 7A； lysine-specific demethylase 7A； [histone H3]-dimethyl-L-lysine9 demethylase 7A； histone lysine demethylase JHDM1D； jmjC domain-containing histone demethylation protein 1D； jumonji C domain containing histone demethylase 1 homolog D； lysine (K)-specific demethylase 7A； lysine-specific demethylase 7； JHDM1D蛋白； 背景信息：
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
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