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磷脂酰肌醇PREX2抗体
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PREX2 半岛bd体育手机客户端 别名： DEP.2； DEPDC2； P-REX2； PPP1R129； PREX2； phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2； phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2； phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein； DEP domain-containing protein 2； PtdIns(3,4,5)-dependent Rac exchanger 2； protein phosphatase 1, regulatory subunit 129； 磷脂酰肌醇PREX2； 背景信息：
PREX2 functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. PREX2 mediates the activation of RAC1 in a PI3K-dependent manner. PREX2 may be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
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