半岛bd体育手机客户端 介绍
靶标：
PDZD3 半岛bd体育手机客户端 别名： IKEPP； NHERF4； PDZK2； PDZD3； PDZ domain containing 3； PDZ domain containing 3； Na(+)/H(+) exchange regulatory cofactor NHE-RF4； NHERF-4； PDZ domain containing 2； PDZ domain-containing protein 2； PDZ domain-containing protein 3； intestinal and kidney enriched PDZ protein； na/Pi cotransporter C-terminal-associated protein 2； naPi-Cap2； natrium-phosphate cotransporter IIa C-terminal-associated protein 2； sodium-hydrogen exchanger regulatory factor 4； PDZ结构域PDZK3蛋白； 背景信息：
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).
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