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四聚体多肽蛋白21B抗体
半岛bd体育手机客户端 介绍
靶标:
Ttc21b 半岛bd体育手机客户端 别名: 2410066K11Rik; Thm1; aln; mKIAA1992; Ttc21b; tetratricopeptide repeat domain 21B; tetratricopeptide repeat domain 21B; tetratricopeptide repeat protein 21B; TPR repeat protein 21B; intraflagellar transport 139 homolog; line 158; tetratricopeptide repeat-containing hedgehog modulator 1; 四聚体多肽蛋白21B; 背景信息:
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
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